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sodium 2-({5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}carbamoyl)-1-hydroxy-4,6-diiodocyclohexa-2,4-diene-1-carboxylate

Closantel Sodium

CAS: 61438-64-0

Molecular Formula: C22H13Cl2I2N2NaO2

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sodium 2-({5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}carbamoyl)-1-hydroxy-4,6-diiodocyclohexa-2,4-diene-1-carboxylate - Names and Identifiers

Name Closantel Sodium
Synonyms CLOSANTEL(NA)
Closan Sodium
Closantel Sodium
CLOSANTEL SODIUM
closantel sodium salt
Closan Sodium (Patented)
Closantel Sodium (Patented)
Chloride sodium cyanide iodine willow amine
Sodium N-(5-chloro-4-((4-chlorophenyl)cyanomethyl)-o-tolyl)-2-hydroxy-3,5-diiodobenzamidate
n-[5-chloro-4-[(chlorophenyl)cyannomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamid sodium salt
sodium 2-({5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}carbamoyl)-4,6-diiodophenolate
sodium 2-({5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}carbamoyl)-1-hydroxy-4,6-diiodocyclohexa-2,4-diene-1-carboxylate
sodium 2-[[5-chloro-4-[(4-chlorophenyl)-cyanomethyl]-2-methylanilino]-oxomethyl]-1-hydroxy-4,6-diiodo-1-cyclohexa-2,4-dienecarboxylate
CAS 61438-64-0
EINECS 262-794-7
InChI InChI=1/C22H14Cl2I2N2O2.Na/c1-11-6-15(17(10-27)12-2-4-13(23)5-3-12)18(24)9-20(11)28-22(30)16-7-14(25)8-19(26)21(16)29;/h2-9,17,29H,1H3,(H,28,30);/q;+1/p-1

sodium 2-({5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}carbamoyl)-1-hydroxy-4,6-diiodocyclohexa-2,4-diene-1-carboxylate - Physico-chemical Properties

Molecular FormulaC22H13Cl2I2N2NaO2
Molar Mass685.06
Melting Point>230°C (dec.)
Boling Point590.5°C at 760 mmHg
Flash Point310.9°C
Vapor Presure1.53E-14mmHg at 25°C
AppearanceSolid
Storage ConditionKeep in dark place,Inert atmosphere,Room temperature
MDLMFCD03427328
UseUsed as an antiparasitic agent
In vitro studyClosantel inhibited drug-resistant Staphylococcus aureus and Enterococcus faecium, MICs 1 μg/mL and 1 μg/mL, respectively. The MRSA MICs inhibited by Closantel was 2 μg/mL. Closantel completely blocks the infection of host cells by E. chaffeensis or A. phagocytophilum, treating in A dose-dependent manner cells persistently infected for one day, thereby clearing the infection. Closantel inhibits the activity of three sensor kinase autokinases from E. chaffeensis. Closantel (50 μg/mL) acts on vascular tissue to induce contractions of greater amplitude and higher frequency than normal. Stimulation at such amplitude and frequency for about 15 minutes is accompanied by an increase in muscle tension, this results in a maximum of 16 min, which is a level greater than 1.5 times the maximum normal amplitude.
In vivo studyClosantel (10 mg/kg) acted on 25 F before administration. Mice with posterior metacercaria of the hepatica family, after 24 hours, cause total surface damage in mice in the form of erosion of the anterior and posterior limbs of the fluke and extensive molting on the back and abdominal surfaces. Closantel (7.5 mg/kg) in combination with a broad-spectrum anthelmintic was very effective against the nematode twister, but not very effective against the genus Strongylus in sheep. Closantel significantly reduced isotope levels in closantel-resistant, adult sheep infected with the twisted blood spear nematode.

sodium 2-({5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}carbamoyl)-1-hydroxy-4,6-diiodocyclohexa-2,4-diene-1-carboxylate - Risk and Safety

HS Code29269090

sodium 2-({5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}carbamoyl)-1-hydroxy-4,6-diiodocyclohexa-2,4-diene-1-carboxylate - Reference Information

, it belongs to the same salicylanilide compound as the iodoethers, and is a new broad-spectrum antiparasitic drug currently used in the aquaculture industry, with the appearance of yellowish powder, odorless or slightly odorous, soluble in ethanol or acetone, soluble in methanol, insoluble in water or in chloroform. The pharmacological effect is to inhibit the phosphorylation process of the mitochondria of the worm, thus preventing the synthesis of adenosine triphosphate (ATP) in the worm, resulting in the rapid weakening of the energy metabolism of the worm and finally dying. Sodium chlorothionamide can completely kill the scabies, blood lice, roundworm, class round nematode, kidney nematode, whipworm, cattle carboxy nematode, supine nematode, radiation esophageal nematode, large flukes, fasciola hepatica, capillary nematode, skin fly maggot, sheep nose fly maggot, tick fly, scabies mite, nematode, Fasciola, horse stomach fly, dog fat mite and other poultry internal and external parasites. For a variety of flukes, nematodes and arthropod larvae have good curative effect; Its anti-flukes repellent activity is mainly aimed at Fasciola hepatica, the larval repellent activity against nematodes and arthropods is mainly directed against various blood-or plasma-sucking worms. Clinical efficacy tests showed that, when administered at a dose of 10mg/kg body weight, the sheep Fasciola hepatica, before and after the disc flukes, pulmonary filariasis and most of the digestive tract nematodes in vitro and in vivo have a complete repellent effect, is the best dose of sheep anthelmintic.
The precautions are as follows:
1. Sodium chlorocyanoiodide injection has certain irritation to local tissues; This product has a long inflammation period in animals and is not easy to be degraded and inactivated.
2, this product is low toxicity, but the bovine muscle injection of 30 mg per kilogram of body weight, can make the visual impairment, blindness, and even death.
3. Drug holiday: tablets and suspension for 28 days; Injection, cattle and sheep for 28 days, and milk for 28 days.
anti-parasitic drugs
biological activity Closantel Sodium is a Gram-positive antibacterial activity inhibitor, which inhibits the Gina/spoof system, the IC50 was 3.8 μm.
Use used as an antiparasitic drug
, gastrointestinal nematodes and arthropod larval stage have repellent activity. Mainly used for the prevention and treatment of cattle, sheep Fasciola, gastrointestinal nematode disease and sheep manic myiasis, such as
Last Update：2024-04-09 21:04:16
sodium 2-({5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}carbamoyl)-1-hydroxy-4,6-diiodocyclohexa-2,4-diene-1-carboxylate
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Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Closantel Sodium Request for quotation
CAS: 61438-64-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: Closantel sodium Visit Supplier Webpage Request for quotation
CAS: 61438-64-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
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sodium 2-({5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}carbamoyl)-1-hydroxy-4,6-diiodocyclohexa-2,4-diene-1-carboxylate
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